Practical Considerations for the Validation of Next-Generation Sequencing-Based Oncology Panels

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SKU:
311HZN18-004

This content was created in 2018, but has been reviewed and approved by the Training & Education Committee as useful, accurate, and relevant. Please note that in the time since this material was posted, there may have been additional developments, advancements, and/or more current publications in this field.

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Description: 

Validation of NGS-based testing for oncology panels can be challenging given the many steps and wide range of targeted mutations. In this presentation, Dr. Jennings will discuss the recent AMP/CAP guideline recommendations for validation and review practical ways to provide documented evidence with the clinical NGS reports.

Learning Objectives:

  • Describe an error-based approach to validation and choose which sources of variation need to be assessed.
  • Estimate the number of samples that are needed to confidently achieve a stated reliability.
  • Use tolerance limits to define minimum QC performance criteria.
  • Compare ways to assess library complexity.

Practice Guideline Available Here

Speaker: Lawrence J. Jennings, MD, PhD
Moderator: Antonia R. Sepulveda, MD, PhD
Duration: 1 hr
Level of Instruction: Basic
Date Recorded: April 25, 2018

Continuing Education Credit Information

CE Credit for this course has expired.

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