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Description:
This presentation summarizes the findings of the Association for Molecular Pathology Chronic Myeloid Neoplasm Working Group. Chronic myeloid neoplasms (CMNs) are defined as a complex group of hematopoietic disorders, encompassing myelodysplastic syndromes (MDS), myeloproliferative neoplasms (MPNs), the overlap entities (MDS/MPNs), and systemic mastocytosis. The goal of this group was to distill the vast amounts of literature on the mutational profiles of the CMNs into high impact information that would aid molecular pathologists in the development of next generation sequencing (NGS) myeloid panels. This work identifies 34 genes as the minimum recommended testing list and provides information on the frequency of these genes in the various CMNs as well as their prognostic and therapeutic import. In addition, the findings highlight the recurrent patterns of mutational clonal evolution in these patients, uncovering critical insight into the biology of these neoplasms.
Learning Objectives:
- List the four main pathways in which there are recurrent mutations in chronic myeloid neoplasms.
- Characterize the common patterns of mutations seen in the chronic myeloid neoplasms.
- Deconstruct the patterns of clonal evolution seen in the chronic myeloid neoplasms.
Practice Guideline Available Here
Speaker: Annette S. Kim, MD, PhDModerator: Todd W. Kelley, MD
Duration: 1 hr
Level of Instruction: Basic
Date Recorded: July 19, 2018
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