CYP3A4 and CYP3A5 Genotyping Recommendations
This contains the webinar recordingContinuing education credit is no longer available for this webinar.
Description:
This webinar is based on new consensus recommendations from the Association for Molecular Pathology to aid in the design and validation of clinical CYP3A4 and CYP3A5 genotyping assays, promote standardization of testing across different laboratories, and improve patient care. The AMP Pharmacogenetics (PGx) Working Group with representation from Clinical Pharmacogenetics Implementation Consortium (CPIC), College of American Pathologists (CAP), Dutch Pharmacogenetics Working Group (DPWG) of the Royal Dutch Pharmacists Association, European Society for Pharmacogenomics and Personalized Therapy (ESPT), Pharmacogenomics Knowledgebase (PharmGKB®), and Pharmacogene Variation Consortium (PharmVar) has developed a series of guidelines designed to help standardize clinical testing for frequently used genotyping assays. The latest report builds on the earlier recommendations for clinical genotyping of TPMT and NUDT15, CYP2C19, CYP2C9, CYP2D6, and genes important for warfarin testing and should be implemented together with other relevant clinical guidelines. The AMP PGx Working Group used the same two-tier categorization of alleles that were recommended for inclusion in the previous clinical PGx genotyping assay guidelines for the latest report.
Learning Objectives:
- Review CYP3A4 and CYP3A5 pharmacogenetics and highlight the importance of standardization of clinical pharmacogenetics and its implications to patient care.
- Review the AMP Pharmacogenetics (PGx) Working Group ‘Tier’ system of pharmacogenetics sequence variants/alleles recommendation.
- Explain the key attributes of Tier 1 and Tier 2 recommended alleles for CYP3A4 and CYP3A5 genotyping.
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| Speaker: Yuan Ji, PhD, DABCP, FACMG |
Moderator: Matthew S. Lebo, PhD, FACMG Director of Bioinformatics at Mass General Brigham Associate Professor of Pathology, Harvard Medical School and Brigham and Women's Hospital |
Duration: 1 Hour
Level of Instruction: Basic
Date Recorded: August 1, 2023
Planned and coordinated by the Clinical Practice Committee and Training and Education Committee
Continuing Education Credit Information
Continuing education credit is no longer available for this webinar.
Note: Members of AMP can access this webinar at no cost. Join the AMP Family!
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