CYP3A4 and CYP3A5 Genotyping Recommendations
This contains the webinar and continuing education credit (CME and CMLE)Description:
This webinar is based on new consensus recommendations from the Association for Molecular Pathology to aid in the design and validation of clinical CYP3A4 and CYP3A5 genotyping assays, promote standardization of testing across different laboratories, and improve patient care. The AMP Pharmacogenetics (PGx) Working Group with representation from Clinical Pharmacogenetics Implementation Consortium (CPIC), College of American Pathologists (CAP), Dutch Pharmacogenetics Working Group (DPWG) of the Royal Dutch Pharmacists Association, European Society for Pharmacogenomics and Personalized Therapy (ESPT), Pharmacogenomics Knowledgebase (PharmGKB®), and Pharmacogene Variation Consortium (PharmVar) has developed a series of guidelines designed to help standardize clinical testing for frequently used genotyping assays. The latest report builds on the earlier recommendations for clinical genotyping of TPMT and NUDT15, CYP2C19, CYP2C9, CYP2D6, and genes important for warfarin testing and should be implemented together with other relevant clinical guidelines. The AMP PGx Working Group used the same two-tier categorization of alleles that were recommended for inclusion in the previous clinical PGx genotyping assay guidelines for the latest report.
Learning Objectives:
- Review CYP3A4 and CYP3A5 pharmacogenetics and highlight the importance of standardization of clinical pharmacogenetics and its implications to patient care.
- Review the AMP Pharmacogenetics (PGx) Working Group ‘Tier’ system of pharmacogenetics sequence variants/alleles recommendation.
- Explain the key attributes of Tier 1 and Tier 2 recommended alleles for CYP3A4 and CYP3A5 genotyping.
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| Speaker: Yuan Ji, PhD, DABCP, FACMG |
Moderator: Matthew S. Lebo, PhD, FACMG Director of Bioinformatics at Mass General Brigham Associate Professor of Pathology, Harvard Medical School and Brigham and Women's Hospital |
Duration: 1 Hour
Level of Instruction: Basic
Date Recorded: August 1, 2023
Planned and coordinated by the Training and Education Committee
Continuing Education Credit Information
CME credit: 1.0CMLE credit: 1.0
Last day to claim credit: March 20, 2025
Accreditation Statements
AMA PRA Category 1 Credit(s)™
This
activity has been planned and implemented in accordance with the
Essential Areas and policies of the Accreditation Council for Continuing
Medical Education through the joint providership of American Society
for Clinical Pathology (ASCP) and Association for Molecular Pathology
(AMP). The American Society for Clinical Pathology (ASCP) is accredited
by the ACCME to provide continuing medical education for physicians.
The ASCP designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only credit commensurate with the extent of their participation in the activity.
CMLE
This continuing medical laboratory education activity is recognized by the American Society for Clinical Pathology for 1.0 hours
of CMLE credit. ASCP CMLE credit hours are acceptable for the ASCP
Board of Certification (BOC) Certification Maintenance Program
(CMP). CMLE credit hours meet the continuing education requirements for
the ASCP Board of Certification Credential Maintenance Program (CMP) and
state relicensure requirements for laboratory personnel. Participants
should claim only the credit commensurate with the extent of their
participation in the activity.
Note: Members of AMP can access this webinar at no cost. Join the AMP Family!
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