This is a recording of a session from AMP Europe 2021 Virtual Meeting. Purchase a bundle of 8 sessions from the AMP Europe 2021 Virtual Conference for a significant discount by clicking this link.
Session Description:
Cancer is characterized by both genetic and epigenetic alterations. While cancer driver mutations and copy-number alterations have been studied at a systems-level, relatively little is known about the systems-level patterns exhibited by their epigenetic counterparts. In this section speakers will perform a pan-cancer wide systems-level analysis, mapping candidate cancer-driver DNA methylation (DNAm) alterations onto a human interactome. The invited speakers demonstrate that functional DNAm alterations in cancer tend to map to nodes of lower connectivity and inter-connectivity, compared to the corresponding alterations at the genomic level. There are findings that epigenetic alterations are relatively over-represented in extracellular and transmembrane signaling domains, whereas cancer genes undergoing amplification or deletion tend to be enriched within the intracellular domain.
Chair: Dr. Massimiliano M. Corsi Romanelli
Presentations:
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Targeting Epigenome in Cancer, Dr. Lucia Altucci
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Deregulation of Hedgehog Signaling in Cancer: Targeting Epigenetic and Metabolic Vulnerabilities, Dr. Gianluca Canettieri
Duration: 50 minutes
Recording Date: June 18, 2021
Last day to purchase: December 31, 2024
There are no CME or CMLE credits available.Note: Join the AMP Family for discounted access to the most current educational resources!
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