Please note that this was recorded in 2017. All AMPEDTM content is reviewed and approved annually by the Training & Education Committee as relevant and accurate, but new data may now be available and new studies may have since been published.
AMP Education is constantly updating these educational offerings, so keep checking back at educate.amp.org for new content, content updates, and information on cutting-edge molecular pathology research and applications.
Description:
This presentation provides an overview of recent advances in the understanding of the molecular pathogenesis of diffuse large B-cell lymphoma, the most common mature B-cell malignancy. The speakers illustrate the most common genes/programs targeted by genetic lesions in this disease, with emphasis on epigenetic modifiers; discuss the role of these genes in normal and malignant B-cells; and highlight how these molecular insights have unveiled novel therapeutic opportunities.
The Genomic Landscape of B-Progenitor Acute Lymphoblastic Leukemia (ALL)
Charles G. Mullighan, MBBS (Hons), MSc, MD, St. Jude Children's Research Hospital, Memphis, TN, USA
Genetic and Epigenetic Drivers of Diffuse Large B Cell Lymphoma (DLBCL)
Laura Pasqualucci, MD, Columbia University Medical Center, New York, NY, USA
Learning Objectives:
- Define the most common structural alterations associated with major DLBCL subtypes and their prognostic significance.
- Explain how these lesions may favor malignant transformation.
- Identify ways to utilize this information for diagnostic and therapeutic purposes.
Duration: 1.50 hr
Recording Date: November 16, 2017
Note: Join the AMP Family for discounted access to the most current educational resources!
All sales are final. No refunds will be issued.
No digital files may be reproduced or transmitted in any form, by any means, electronic or mechanical. By purchasing a product, you agree to not share any of the course materials, including videos, downloadable slide presentations, outlines, manuscripts, etc. without explicit and written permission from AMP.
