Methylation of CpG dinucleotides is a key epigenetic regulator of gene function during development and disease. DNA methylation-based biomarkers can be useful targets in the diagnosis and prognosis of tumors. This session will focus on methods used for methylation analysis, integration of DNA methylation results with histopathology and NGS methods and clinical applications for tumor subclassification.
DNA Methylation and Machine Learning in Molecular Pathology for Diagnosis and Clinical Management
Matija Snuderl, MD, NYU Langone Medical Center, New York, NY, USA
Objectives:
- Discuss the importance of DNA methylation on gene expression and methods for analysis.
- Identify pre-analytical variables affecting DNA methylation based classifiers
- Integrate DNA methylation results with histopathology and next-generation sequencing methods
Duration: 0.50 hr
Recording Date: November 9, 2019
CME/CMLE credit: 0.50 hr
Last day to purchase course and CE claim credit: December 24, 2022